fill

PublicationsPublications

Translating multiomics prediction into clinical care in Crohn's disease: Moving beyond proof of concept

05/17/2026

No abstract

DNA methylation biomarkers associated with early gastric cardia carcinogenesis

05/17/2026

Gastric cardia cancer (GCC) is an aggressive malignancy with poor prognosis, underscoring the need for better characterization of molecular alterations during early gastric cardia carcinogenesis. This study aimed to identify and validate tissue-based DNA methylation markers associated with early precancerous and neoplastic lesions of the gastric cardia. We integrated genome-wide DNA methylation data (850 K array) from 69 gastric cardia samples, including normal mucosa (n = 22), intestinal...

Bile acid metabolism dysregulation following Helicobacter pylori eradication promotes plasmid-mediated antimicrobial resistance in the gut microbiome

05/17/2026

Antimicrobial resistance (AMR) transmission within the gut microbiome poses a major health risk during antibiotic exposure, primarily via horizontal gene transfer (HGT). However, how antibiotic-induced metabolic remodeling of the intestinal environment modulates plasmid-mediated AMR dissemination remains unclear. Herein, integrating metagenomics, metabolomics, in vitro conjugation assays, and in vivo mouse models, we show that Helicobacter pylori eradication therapy reshapes gut metabolism in...

Exclusive enteral nutrition improves radiological outcomes in adults with perianal fistulizing Crohn's disease: A real-world retrospective cohort study

05/17/2026

CONCLUSIONS: EEN treatment was associated with improved radiological and clinical outcomes in patients with PFCD.

Comments on "Immune Checkpoint Inhibitor-Based Adjuvant Treatment Versus Surveillance in Curatively Treated Hepatocellular Carcinoma: A Systematic Review and meta-Analysis"

05/17/2026

No abstract

One Chromatin, Many Structures: From Ensemble Contact Maps to Single-Cell 3D Organization

05/17/2026

Understanding how chromatin folds in three dimensions remains challenging because most experimental assays capture low-dimensional projections of an underlying, highly heterogeneous polymer. Here we present an ensemble-based interpretive framework built on the previously introduced Self-Returning Excluded Volume (SR-EV) model, a minimal generator of chromatin conformations using a nucleosome-indexed coarse-grained representation based on stochastic return rules and excluded-volume geometry....

The JAK Inhibitor Paradox: A Mechanistic Divide Between Adaptive and Innate Immunity

05/17/2026

No abstract

CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis

05/16/2026

CONCLUSIONS: These studies provide a comprehensive single-cell proteogenomic atlas of CD4+ T cells in MASH and identify an OX40-dependent CD4+ T cell-macrophage axis as a promising therapeutic target for the treatment of MASH and liver fibrosis.

A case of carbapenamase production in <em>Shigella flexneri</em> isolated in Ireland, 2025

05/16/2026

Shigella flexneri producing OXA-181 was detected from a patient in Ireland in October 2025. The isolate had a meropenem minimum inhibitory concentration (MIC) of 0.12 mg/L. Carbapenemase production was detected by lateral flow immunoassay. The sequence type was ST245 and closely related to sequences previously reported from Ireland and other countries but not previously linked to presence of the bla (OXA-181) gene(.) Carbapenemase production in Shigella spp. has implications for laboratory...

Gastric Cancer Incidence After Helicobacter pylori Eradication and Lifestyle-Related Risk Factors: A Population-Based Cohort Study

05/16/2026

CONCLUSION: GC remains a clinically important outcome even after Hp eradication. Smoking was associated with a higher risk of post-eradicated GC, and smoking cessation may contribute to risk reduction in this population. These findings suggest that lifestyle factors, together with host characteristics such as age, male sex, and alcohol consumption, may be considered when designing risk-stratified surveillance strategies.

First Report of National Consensus Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Iran

05/16/2026

CONCLUSION: This national guideline provides a standardized, evidence-based framework for improving H. pylori diagnosis and management. By integrating local antimicrobial resistance patterns and practical clinical considerations, the guideline helps optimize eradication rates, reinforce antibiotic stewardship, and contribute to gastric cancer prevention efforts across Iran.

Elucidating the Pathogenic Role of Helicobacter pylori Infection in Hematologic Disorders: Mechanistic Insights and Future Perspectives

05/16/2026

Helicobacter pylori (H. pylori), a helical, flagellated Gram-negative bacterium, exhibits remarkable adaptability within the human gastric niche, enabling survival under acidic, nutrient-limited, and oxidative stress conditions. Beyond its established role in gastritis, peptic ulcer disease, and gastric adenocarcinoma, accumulating evidence implicates H. pylori in a spectrum of hematologic disorders. Iron deficiency anemia (IDA), vitamin B12 deficiency, immune thrombocytopenic purpura (ITP), and...

Efficacy and Safety of Vonoprazan-Based Dual Therapies With Different Antibiotics Versus Bismuth-Containing Quadruple Therapy for Helicobacter pylori Eradication: A Prospective, Four-Arm, Randomized Controlled Trial

05/16/2026

CONCLUSION: Vonoprazan-based regimens showed no statistically significant between-group differences in eradication and were associated with good adherence overall. In our setting, VA and VM may represent practical simplified options, whereas VT appeared less robust as an empiric regimen. These exploratory findings warrant confirmation in larger, adequately powered randomized trials.

High Eradication Rate of a Potassium-Competitive Acid Blocker-Based Minocycline, Furazolidone, and Bismuth Regimen for Refractory Helicobacter pylori Infection: A Real-World Study

05/16/2026

CONCLUSIONS: The 14-day regimen of P-CAB, minocycline, furazolidone, and bismuth is highly effective and well tolerated in patients with refractory H. pylori infection. This regimen represents a promising empirical rescue therapy, particularly in settings where antimicrobial susceptibility testing is unavailable.

A Bidirectional Association Between Helicobacter pylori Infection and Hyperlipidemia: Clinical Evidence and Mechanistic Insights

05/16/2026

CONCLUSION: These findings define a microbiota-host lipid transport axis linking chronic H. pylori infection to dyslipidemia and suggest that integrated targeting of microbial infection and metabolic dysfunction may offer therapeutic benefit.

Antibiotic-associated <em>Enterococcus</em> expansion in the gastrointestinal tract precedes infected necrosis in acute necrotizing pancreatitis

05/16/2026

Infected pancreatic necrosis complicates 30% of necrotizing pancreatitis cases, with intestinal bacterial translocation as the presumed mechanism. To characterize gastrointestinal microbiota dynamics preceding infection, we performed a predefined subgroup analysis of the POEMA cohort, a prospective multicenter microbiota study across 20 Dutch hospitals. Of 276 patients with acute pancreatitis, 57 with necrotizing pancreatitis underwent twice-weekly rectal and salivary sampling for 30 d, analyzed...

A Real-World Experience of Prognostic Factors of Survival Outcomes in a Taiwanese Population With Unresectable Hepatocellular Carcinoma Treated With First-Line Lenvatinib

05/16/2026

CONCLUSION: Lenvatinib is effective in real-world treatment of unresectable HCC, especially when combined with LRT. ALBI grade 1 and AFP ≤ 400 ng/mL are favorable prognostic indicators for survival and disease control. These findings support personalized treatment strategies and warrant further prospective validation.

HLA-B*44 Alleles and HLA-DQA1*03:01 as Genetic Risk Factors for Drug-Induced Liver Injury due to Fluoroquinolones

05/16/2026

CONCLUSIONS: A novel HLA-B*44 association with fluoroquinolone-induced liver injury has been identified and a previously reported but weaker association with HLA-DQA1*03:01 confirmed. The B*44 findings suggest a mechanism involving inappropriate recognition of drug-modified self peptides by serine-167 in pocket A of the HLA-B protein.

Clinical Performance of Computer-Aided Detection System for Gastric Neoplasms: A Non-Randomized Confirmatory Trial (G-CADe Trial) (With Video)

05/16/2026

CONCLUSIONS: LCI-CAD EYE demonstrated a high sensitivity for known gastric epithelial neoplasms in a clinical setting.

Tie2 inhibition disrupts TMEM doorway function and reduces dissemination in pancreatic ductal adenocarcinoma

05/16/2026

CONCLUSIONS: Intravasation and dissemination is TMEM doorway mediated in PDAC. TMEM doorway function is mediated by Tie2 signaling. Inhibition of Tie2 pharmacologically and genetically decreases TMEM doorway function and PDAC dissemination. Tie2 inhibition may have therapeutic potential combined with chemotherapy or emerging therapies for PDAC.
sectionimg
dotimg

Download the app and start using it now

appstore Download on the App Store playstore GET IT ON Google Play

© 2026 Gastroenterology & Hepatology Advance Practice Providers, All rights reserved.