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PublicationsPublications

Effects of Improved Sleep and Gastric Vagotomy on Serum Inflammatory Mediators in Peptic Ulcer Rats

13/09/2025

CONCLUSION: Improved sleep can enhance vagal nerve excitability, decrease inflammatory mediator release, and support the healing of peptic ulcers.

Interpretable Multimodal Fusion Model Enhances Postoperative Recurrence Prediction in Gastric Cancer

13/09/2025

Accurate prediction of early postoperative recurrence in locally advanced gastric cancer (LAGC) remains challenging due to tumor heterogeneity and limitations of traditional clinicopathological factors. This study aims to develop and validate an interpretable multimodal model for precise recurrence prediction. 1580 LAGC patients are enrolled from six Chinese medical centers and a multimodal fusion Risk Stratification Assessment (RSA) model integrating clinical, radiomic, and pathomic data is...

Coxsackievirus B3 Inhibited Colorectal Cancer by Upregulating miR-214-3P and Promoting Ferroptosis

13/09/2025

IntroductionColorectal cancer (CRC) is the third most common cancer worldwide and a significant public health threat with far-reaching societal implications. The currently available CRC therapeutic strategies have limitations, thus requiring the development of new strategies. Coxsackievirus B3 (CVB3) exhibits strong oncolytic activity in CRC, although its mechanism of action remains unclear. This study aimed to investigate whether the induction of ferroptosis is a promising treatment strategy...

Personalized Medicine in Cystic Fibrosis: Characterization of Eight Rare CFTR Variants in Intestinal Organoids and Cellular Models

13/09/2025

CONCLUSIONS: This work highlights the importance of using patient-derived intestinal organoids as a theranostic tool to predict the clinical benefit and thus increase the number of people with cystic fibrosis with access to the currently approved CFTRm therapies. While theratyping in cell lines is a valuable approach, additional testing in cystic fibrosis-derived organoids provides more reliable predictions for the individuals carrying rare CFTR variants.

Addressing unmet needs in Lynch syndrome: a patient-centered meeting to foster education, emotional support, and shared decision-making

13/09/2025

No abstract

Severe Primary Epstein-Barr Virus Infection in a Young Female with Crohn's Disease Treated with Upadacitinib

13/09/2025

No abstract

Rectal Metastasis Mimicking Inflammatory Bowel Disease

13/09/2025

No abstract

GARP-expressing Tregs as a source of immunosuppressive TGF-β1 in human tumors

13/09/2025

Most cells produce latent transforming growth factor-beta 1 (TGF-β1), but only very few activate the cytokine via cell type-specific mechanisms. TGF-β1 favors cancer progression by suppressing anti-tumor T cell responses. Which cells produce this immunosuppressive TGF-β1 in human tumors is unknown. Putative sources include cells expressing the glycoprotein A repetitions predominant (GARP) protein, comprising mostly activated regulatory T cells (Tregs) (GARP^(+)FOXP3^(+) cells) and blood...

Induction chemotherapy followed by long-course chemoradiotherapy versus short-course radiotherapy followed by consolidation chemotherapy for achieving complete response in patients with locally advanced rectal cancer: a propensity-score matching study

13/09/2025

CONCLUSIONS: In the matched cohort of mainly intermediate-risk cases, INCT-LCCRT and SCRT-CNCT demonstrated comparable CR rates and oncological outcomes.

HCV Elimination Strategies for Maximum Effectiveness, Tailored to National and Regional Circumstances

13/09/2025

No abstract

Asthma treatment response modified by fine particulate matter, nitrogen dioxide, and ozone among Black children: A reanalysis of the AsthmaNet Best African American Response to Asthma Drugs trial

13/09/2025

No abstract

Lenvatinib Versus Atezolizumab Plus Bevacizumab as First-Line Treatment for Advanced Hepatocellular Carcinoma With a CRAFITY Score of 2: A Multi-Center Retrospective Study

13/09/2025

CONCLUSION: Lenvatinib provided a significantly longer PFS than Atezo+Bev in patients with HCC and a baseline CRAFITY score of 2, whereas OS did not significantly differ between the two groups. These findings may serve as a cornerstone for developing biomarker-based strategies in first-line treatment selection for this patient population.

Clinical and Genetic Predictors of Non-Alcoholic Steatotic Liver Disease and Fibrosis in Lean Individuals

13/09/2025

CONCLUSION: Diabetes serves as a primary predictor of non-alcoholic SLD in lean individuals. These results support the recommendation to screen for SLD in patients with diabetes, regardless of BMI. The GCKR risk allele is associated with MASLD in lean individuals, and the risk factors for cryptogenic SLD remain unclear.

Prevalence of Serologically Defined Celiac Disease in Patients With Irritable Bowel Syndrome in Asia: A Multicountry Hospital-Based Study

13/09/2025

CONCLUSION: Overall prevalence of serologically defined CeD in Asian patients with IBS is 2.75% but differs across patient profiles. This study suggests the need for better awareness and further studies on the prevalence of CeD across Asia.

Secretory IgA Is a Key Marker Among Gut Barrier Dysfunction-Related Immunoglobulins Predicting Outcomes in ACLF

13/09/2025

CONCLUSION: Enhanced BT-triggered immune activation is indicated by increased total-IgA levels in association with the occurrence of target-specific IgA antibodies. Serum sIgA is a promising marker of gut barrier failure and 90-day mortality in ACLF.

A Triple Perspective on the Triple Visit: Protocol for a Mixed Methods Evaluation of the Implementation of a Pediatric Multidisciplinary Clinic Model for Inflammatory Bowel Disease

12/09/2025

CONCLUSIONS: Given that this clinic model is relatively new, this protocol will provide sound methodological direction for other studies that aim to evaluate or implement this type of model in their setting. The evaluation itself will provide comprehensive insights into both the successes and challenges of implementing a multidisciplinary approach that provides a holistic model of care for pediatric patients with IBD. As such, this evaluation will be foundational in providing an applied...

Lung Disease in Children With Laryngotracheoesophageal Clefts

12/09/2025

INTRODUCTION: Laryngotracheoesophageal clefts (LTEC) are aspiration-related lesions often assessed using swallow studies and symptoms like respiratory or feeding difficulties. However, these indicators are unreliable predictors of disease severity. Lung inflammation and injury, though significant concerns, are rarely and inconsistently evaluated or reported. As a result, the correlation between swallow study findings and actual pulmonary disease remains unclear.

Next-Generation Noninvasive Colorectal Cancer Screening

12/09/2025

Noninvasive tests for colorectal cancer (CRC) screening in average-risk individuals continue to evolve, with the premise of increasing screening participation among eligible individuals. In addition to fecal immunochemical testing (FIT), which has become the noninvasive standard for which to improve sensitivity for detecting CRC and specificity for detecting the absence of CRC, new US Food and Drug Administration-approved tests include the detection of DNA in a next-generation multitarget stool...

RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis

12/09/2025

Current treatments for pancreatic ductal adenocarcinoma (PDAC) fall short of meeting clinical needs, highlighting the urgent need for a comprehensive understanding of PDAC progression, which involves not only biochemical signals but also essential biomechanical cues. Here, we used a CRISPR-Cas9 screen in an orthotopic xenograft model to explore PDAC dynamics. The RNA binding protein DEAD-box helicase 3X-linked (DDX3X) was identified as a pivotal oncogene and biomechanical checkpoint....

Trend analysis and projection of the gastric cancer disease burden in Taiwan during 1990-2021: An analysis of the global burden of disease study 2021

12/09/2025

CONCLUSIONS: Across the past 32 years, gastric cancer in Taiwan has exhibited a declining relative burden, yet the absolute burden has risen consistently and is forecast to keep increasing over the next 15 years. Precision risk control measures and context-specific public health policies are required to alleviate this burden.
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