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PublicationsPublications

Performance indicators for organ donation and transplantation programmes in Europe: modified Delphi consensus study

01/22/2026

CONCLUSION: This validated indicator set provides a standardized tool for assessing and comparing transplant system performance across European countries, supporting performance benchmarking and evidence-informed policy development.

Progressive Left Mandibular Swelling in a Young Man

01/22/2026

No abstract

High copper levels induce oxidative stress and inflammatory processes in a cell culture model of Wilson's disease

01/22/2026

No abstract

An Improved Dual-Opening Submucosal Tunnel Endoscopic Resection (STER) for a Huge Esophageal Leiomyoma

01/22/2026

No abstract

Targeting Vascular Calcification: Novel Insights into Molecular Pathways and Clinical Interventions

01/22/2026

Vascular calcification (VC), a pathological hallmark of advanced atherosclerosis, exerts a profound impact on arterial stiffness and the incidence of cardiovascular disease. Its development involves not only actively regulated biological processes but also passive mineral deposition and is particularly prevalent in patients with diabetes, chronic kidney disease, and endocrine disorders. Although conventional therapies-such as phosphate binders, calcium channel blockers, bisphosphonates, and...

Association between endo-histological outcomes and colonic mucosal transcriptomic profiles in patients with ulcerative colitis receiving filgotinib

01/22/2026

CONCLUSIONS: Filgotinib improved endo-histological outcomes in patients with UC, with a dose-dependent effect on transcription. Gene expression changes and enriched pathways suggest that achieving endoscopic and histological endpoints in patients receiving FIL was associated with the restoration of mucosal homeostasis.

Additional diagnostic value of cervical ultrasound in the detection of cervical lymph node metastases in patients with esophageal cancer

01/22/2026

In Western Europe, esophageal cancer patients with cervical lymph node metastases are considered to have stage IV disease and are generally not eligible for curative treatment. While cervical ultrasound was part of standard diagnostic workup, its added value after negative 18FDG PET-CT is debated, and ultrasound is no longer in the Dutch guideline as standard workup modality. This study assessed the diagnostic accuracy of ultrasound for the detection of cervical lymph node metastases in...

Non-invasive staging of hepatic steatosis by Quantification Attenuation Index (QAI)

01/22/2026

CONCLUSIONS: QAI is a reliable, non-invasive method for assessing hepatic steatosis, with good agreement with histology and with CAP.

Real World Evidence of Clinical Outcomes of First-Line Chemotherapy in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Patients

01/22/2026

CONCLUSION: In the first-line treatment of PDAC, (m)FOLFIRINOX exhibited higher ORR and PFS than GEM or GEMCAPE. However, no survival advantage was observed in the (m)FOLFIRINOX group, suggesting an influence of subsequent therapy.

Significance of Total Colonoscopy Based on the Outcome of Advanced Colorectal Cancer in Older Individuals

01/22/2026

CONCLUSION: TCS facilitates early detection and improves prognosis in older patients with advanced CRC, supporting its use in appropriately selected individuals.

Urinary titin as a potential biomarker of sarcopenia and its association with postoperative complications in colorectal cancer patients

01/22/2026

CONCLUSION: Urinary titin may serve as a potential marker associated with postoperative complications.

Epidemiology of inflammatory bowel disease in southern Spain - A population-based study of native and migrant populations (2012-2022)

01/22/2026

CONCLUSIONS: The prevalence and incidence of IBD in Granada have increased over the last decade but remain lower than those in northern Europe. Migrant populations exhibit lower disease severity. The Mediterranean diet and universal healthcare access may mitigate differences in disease progression.

Impact of using waist-to-height ratio for diagnosing obesity in general digestive outpatient consultations

01/22/2026

CONCLUSIONS: The use of WtHR in gastroenterology consultations allows for better identification of abdominal obesity, especially in patients with digestive and metabolic comorbidities. Its systematic incorporation alongside BMI can improve the clinical and therapeutic approach to these patients.

Efficacy and safety of endoscopic resection of appendiceal lesions. A Spanish multicenter study

01/22/2026

CONCLUSIONS: Endoscopic management of AO lesions is effective and safe. However, recurrence risk emphasizes the need for long-term follow-up. Further research is required to assess delayed appendicitis risk and the optimal management of deep extension AO lesions.

Left atrial appendage closure for atrial fibrillation patients at high risk of gastrointestinal bleeding. An evidence-based multidisciplinary review for gastroenterologists

01/22/2026

CONCLUSIONS: LAAC offers a treatment option for stroke prevention in AF patients in whom lifelong anticoagulation is contraindicated due to recurrent GIB, chronic anaemia or high bleeding risk. In cirrhotic patients, careful selection and shared decision-making are critical due to its higher complications risk.

Silencing PAR-2 in macrophages promotes PANoptosis and triggers duodenal microinflammation in functional dyspepsia

01/21/2026

Macrophage PANoptosis may play a critical role in the development of functional dyspepsia (FD). It not only affects the balance and regulation of the immune system but also participates in the pathogenesis of FD, possibly by affecting the motor and sensory functions of the gastrointestinal tract. In this study, key genes related to PANoptosis and macrophages were identified using weighted gene co-expression network analysis (WGCNA) and Mendelian randomization. Their function was further explored...

When artificial intelligence guides and misguides clinicians: A critical appraisal of AI recommendation correctness and diagnostic decision-making

01/21/2026

No abstract

ROTEM-detected hypocoagulability is associated with major non-portal hypertensive bleeding in cirrhosis

01/21/2026

CONCLUSIONS: ROTEM-detected hypocoagulability was independently associated with major NPH bleeding in cirrhosis. Its clinical implications warrant further investigation.

Genome-wide CRISPR screen identifies ACSL3 as a regulator of lipotoxicity and progression of MASLD

01/21/2026

CONCLUSIONS: ACSL3 is a central regulator of lipotoxic hepatocyte injury and MASLD progression, mechanistically linking lipid-droplet biogenesis to apoptosis and inflammatory niche formation. These data suggest that ACSL3 is a promising therapeutic target and support further translational studies to evaluate ACSL3 modulation in steatotic liver disease.

HER2 Protein Overexpression, mRNA Expression, and DNA Amplification Across Solid Tumors: Comparison of Next-Generation Sequencing-Based Assays With Immunohistochemistry

01/21/2026

CONCLUSION: HER2-positive status in protein, mRNA, and DNA showed concordance in general but varied among tumor types. NGS-based assays, especially WTS, could be a useful predictive tool for HER2 testing in tumor-agnostic settings. Intratumor heterogeneity in HER2 protein expression should be considered when bringing bulk sequencing tests into clinical settings.
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