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PublicationsPublications

Six Minutes' Walk Test and Handgrip Strength Associated with Increased Health-Related Quality of Life in Patients with Colorectal Cancer

28/10/2025

CONCLUSIONS: Our results suggest that greater 6MWT performance and upper-body muscle strength are associated with better functioning and lower symptom burden. Additionally, greater aerobic fitness was linked to better cognitive function. These findings underscore the potential importance of physical fitness for quality of life in cancer survivors and highlight the need for future interventional studies to determine whether improving fitness through rehabilitation strategies can enhance patient...

Maternal undernutrition exacerbates microbiota-driven growth stunting through pre- and postnatal effects

28/10/2025

Linear growth stunting due to undernutrition affects 20% of children under the age of 5, with far-reaching consequences, including increased susceptibility to infection and altered cognitive development. Current nutritional interventions are largely ineffective in rescuing linear growth. A significant proportion of stunting originates in utero; however, the mechanisms by which maternal undernutrition is transmitted between generations remain poorly characterized. Here, we employ a gnotobiotic...

Switching from a High-Fat to a Regular Chow Diet Improves Obesity Progression in Mice

28/10/2025

The fast-paced lifestyle of modern people has changed their dietary structure and increased the prevalence of obesity, of which a high-fat diet is the main cause. Therefore, this study investigates whether reducing fat intake can improve obesity and physical health. We induced an obese model with a 60 kcal% fat diet (HFD) for 12 weeks, followed by an intervention with a 4.9 kcal% fat diet (regular chow diet, RD) for 20 weeks. We found that after 20 weeks of RD, various indicators were...

Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization

28/10/2025

Exosomes are signaling messengers facilitating intercellular communication by delivering molecular cargo. Here, we observed increased levels of exosomal periostin (POSTN) in the blood plasma of patients with proliferative diabetic retinopathy (PDR). Monocytes contributed to elevated levels of exosomal POSTN, and deletion of Postn in myeloid cells reduced retinal neovascularization (RNV). Monocytes isolated from the blood of PDR patients or under high glucose conditions exhibited heightened...

Determinants of Pubertal Growth Spurt in Constitutional Delay of Growth and Puberty in Boys Treated With Testosterone

28/10/2025

CONCLUSION: At six months and one year after the last testosterone injection, the weight, BMI, growth velocity, IGF-1 concentrations and testosterone levels were higher than at baseline, and puberty progressed when compared to baseline. Testosterone levels six months after completion of testosterone cypionate were positively correlated with growth velocity confirming the effect of sex steroids in pubertal growth.

Potential effects of MPs and their co-pollutants on human intestinal tract

28/10/2025

Microplastics (MPs), which are tiny plastic particles measuring less than 5 mm, have sparked public concern in recent years. When exposed to the environment, MPs absorb a variety of pollutants, leading to joint damage to human digestive system and other tissues. Human exposure to MPs mainly through food intake, resulting in potential risk of intestinal tract. Research have demonstrated that MPs compromise intestinal integrity and disrupt microbiota, as well as traverse into systemic circulation,...

Risk Factors for Foodborne Zoonoses Among Populations With and Without a Migration Background in Berlin, Germany

28/10/2025

Knowledge gaps exist regarding foodborne zoonotic diseases in migrant populations. We assessed the seroprevalence of Campylobacter, Salmonella, Yersinia, Brucella, hepatitis E virus (HEV), and Trichinella, and identified potential exposure risks in populations with and without migration backgrounds. In a cross-sectional study (2014-2016), adults with Turkish, Russian, Vietnamese, or German backgrounds residing in Berlin, Germany, were recruited via convenience sampling. Sera were screened for...

Tailored Therapy vs. Empirical Therapy for <em>Helicobacter pylori</em> Eradication: An Umbrella Review of Systematic Reviews and Meta-Analyses

28/10/2025

Objective: This study aimed to provide the first umbrella review to systematically evaluate the evidence for the efficacy of personalized susceptibility-guided tailored therapy (TT) versus empirical therapy (ET) for Helicobacter pylori eradication. Methods: An umbrella review was conducted following Joanna Briggs Institute standards, registered in PROSPERO (CRD420251104335). A comprehensive literature search across MEDLINE/PubMed, EMBASE, RSCI, and Google Scholar identified systematic reviews...

Primary Care Clinician Preferences and Perspectives on Multi-Cancer Detection Testing Across an Integrated Healthcare System

28/10/2025

Background/Objectives: Multi-cancer detection (MCD) tests have emerged as a promising tool to redefine the landscape of early cancer detection. Implementation of this novel technology will likely fall to primary care clinicians (PCC). The purpose of this study is to characterize and explore differences in PCCs perceptions and preferences towards MCD testing. Methods: Between March and May of 2023, this cross-sectional survey was administered to 281 PCCs, including physicians and advanced care...

A Paired Flow Cytometry-Pathology Assessment for Immune Cell Detection in Intestinal Biopsies: Proof of Principle

28/10/2025

Accurate quantification of immune cell subpopulations is essential for understanding immune responses in research and clinical settings. Flow cytometry (FC) is widely used for immune cell phenotyping, providing rapid and quantitative single-cell resolution. However, tissue-based pathological assessment offers additional spatial and morphological context that is often necessary for a comprehensive understanding of immune cell distribution. Traditionally, these methods are applied separately to...

A Practical Guide to Developing and Troubleshooting Patient-Derived "Mini-Gut" Colorectal Organoids for Clinical Research

28/10/2025

Patient-derived organoids (PDOs) have emerged as powerful tools in personalized medicine applicable to both non-malignant conditions and to cancer, where they are increasingly used for personalized drug screening and precision treatment strategies in part due to their ability to replicate tumor heterogeneity. They also serve as study model systems to understand disease mechanisms, pathways, and the impact of ex vivo exposures. We present a detailed step-by-step protocol for generating organoids...

Polyethyleneimine-Assisted Fabrication of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Tamibarotene (Am80) for Meflin Expression Upregulation

28/10/2025

Tamibarotene (Am80) is a promising anti-tumor drug that induces the expression of Meflin (a glycosylphosphatidyl inositol-anchored protein) in cancer-associated fibroblasts, thereby improving the tumor microenvironment. However, Am80, which is approved only for oral administration owing to its poor water solubility, has the challenge of poor tumor penetration. In this study, we developed poly(lactic-co-glycolic acid) nanoparticles loaded with Am80 (Am80-PLGA nanoparticles) as a potential...

Advancing Clinical and Pathophysiological Insights into Pancreatitis Using Lipidomics and Metabolomics

28/10/2025

Acute pancreatitis (AP) and chronic pancreatitis (CP) are distinct inflammatory conditions with significant clinical burden, including associated complications and mortality. These pancreatic conditions share overlapping pathophysiologic features. Although AP can be followed by recurrent episodes (recurrent acute pancreatitis, RAP), most CP does not follow a simple linear progression from AP; rather, CP reflects sustained processes causing injury to the pancreas (e.g., toxic-metabolic, genetic,...

Personalized Nutrition in Pediatric Chronic Diseases

28/10/2025

This narrative review examines the application of personalized nutrition (PN) through multi-OMICS and trans-OMICS in pediatric populations, particularly in relation to chronic conditions such as obesity, type 2 diabetes, and celiac disease. We synthesize evidence to identify biomarkers and gene-environment interactions and translate molecular insights into individualized dietary guidance. Even though PN represents a promising strategy for optimizing child health, significant challenges remain in...

Comparative Prognostic Roles of β-Catenin Expression and Tumor-Stroma Ratio in Pancreatic Cancer: Neoadjuvant Chemotherapy vs. Upfront Surgery

28/10/2025

The benefit of neoadjuvant chemotherapy (NAC) over upfront surgery (UFS) for resectable pancreatic ductal adenocarcinoma (PDAC) is increasingly recognized, yet prognostic biomarkers remain undefined. We evaluated tumor-stroma ratio (TSR), β-catenin (β-CTN) expression, and tumor budding (TB) in 84 resected PDACs (35 NAC, 49 UFS) using digital image analysis of multi-cytokeratin (m-CK) and β-CTN immunohistochemistry. TSR was defined as the proportion of malignant epithelial area within the tumor,...

Perspectives on Racial and Ethnic Health Equity in Systematic Reviews and Evidence-Based Guidelines

27/10/2025

Evidence synthesis and guideline groups have the potential to address health disparities. In June 2024, the Agency for Healthcare Research and Quality (AHRQ) and the Robert Wood Johnson Foundation (RWJF) cosponsored a summit to address racial and ethnic health equity in systematic reviews and other syntheses and guidelines, with support from Cochrane US. This article summarizes cross-cutting themes around future directions for systematic reviews and guidelines. Discussions addressed include the...

A Summary of Guidance on Addressing Racial and Ethnic Health Equity in Systematic Reviews and Evidence-Based Guidelines

27/10/2025

Racial and ethnic health equity is the absence of unfair and avoidable or remediable differences in health and well-being among persons belonging to different racial and ethnic groups. This article summarizes current guidance and identifies practices for systematic reviewers and guideline groups to develop clinical practice guidelines that mitigate such inequities. Current guidance recommends that systematic reviews and clinical practice guidelines ensure a wider perspective; identify,...

The Mediterranean Diet for Irritable Bowel Syndrome : A Randomized Clinical Trial

27/10/2025

CONCLUSION: The MD showed noninferiority and superiority to TDA in managing IBS symptoms. It represents a viable first-line dietary intervention for IBS.

A Search of the ECRI Guidelines Trust for Evidence-Based Guidelines Addressing Racial and Ethnic Health Equity

27/10/2025

Clinical practice guidelines (CPGs) may not consistently address racial and ethnic health equity (RHE). This article discusses an audit of CPGs in the ECRI Guidelines Trust (EGT) aiming to summarize the extent and context in which CPGs address RHE, determine use of race-based recommendations, and determine inclusion of patient or public perspectives representing a racially or ethnically diverse group.

Addressing Racial and Ethnic Health Equity in Systematic Reviews and Evidence-Based Guidelines: Overview and Background for the Series

27/10/2025

Systematic reviews and other evidence synthesis products support clinical practice guidelines, policy and coverage decisions, and future research directions. These products can help promote health equity by examining why differences in outcomes exist, how underrepresentation or overrepresentation in the evidence affects generalizability, and how to address underlying societal sources of disparities. This article provides an overview of and background for a series of articles sponsored by the...
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