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PublicationsPublications

Unveiling the hidden cause behind painless lower gastrointestinal bleeding in an adult - Meckel's Diverticulum: A case report

08/07/2025

CONCLUSION: Meckel's Diverticulum can be thought of as one of the differentials in patients with painless rectal bleeding. Patient should be investigated for Meckel's if no other pathology is identified. Early diagnosis and treatment decrease the morbidity and mortality.

Improving the Readability of Institutional Heart Failure-Related Patient Education Materials Using GPT-4: Observational Study

08/07/2025

CONCLUSIONS: GPT-4 significantly improved the readability of institutional heart failure-related PEMs. The model may be a promising adjunct resource in addition to care provided by a licensed health care professional for patients living with heart failure. Further rigorous testing and validation is needed to investigate its safety, efficacy, and impact on patient health literacy.

Clinical Characteristics and Treatment Outcomes of Colorectal Cancer in Jordan, a Resource-Restricted Country

08/07/2025

CONCLUSION: One third of all patients with colorectal cancer are diagnosed with metastatic disease, which explains the lower survival rates observed compared with Western countries. Programs and initiatives focused on the prevention and early detection of colorectal cancer should be a national priority.

Epigenomic Control of Immunity: From Mechanisms to Therapeutic Targets in Inflammatory Bowel Diseases

08/07/2025

This review presents an overview of the emerging roles of epigenomic regulation in immune cell function, with a particular focus on its relevance in inflammatory bowel disease (IBD). Epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs, are essential in directing immune cell development, activation, and lineage commitment. Advances in genomics and epigenomics have highlighted the dynamic nature of gene regulation as the cornerstone of...

Building bridges: The power of near-peer mentorship in hepatology

08/07/2025

Mentorship is paramount for success in academic medicine, impacting personal and professional growth. Traditional mentorship forms the backbone of mentorship in academic medicine and has many benefits including perspective and sponsorship opportunities. Traditional mentorship, however, has some limitations, especially for individuals at smaller institutions or those traditionally underrepresented in medicine. Lateral mentorship with near peers is a potential adjunctive form of mentorship that...

Adequacy of disclosures in oral presentations at the 20th Congress of European Crohn's and Colitis Organisation

08/07/2025

No abstract

MR Cell Size Imaging Revealing Intestinal Fibrosis to Predict Intestinal Disease Progression in Patients with Crohn's Disease

08/07/2025

CONCLUSIONS: TD-dMRI-derived d serves as a noninvasively microstructural biomarker for intestinal fibrosis in CD, which significantly enhances the accuracy in predicting disease progression risk.

Correction to: Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option

08/07/2025

No abstract

Health Maintenance and Unique Health Needs of the Perimenopausal and Postmenopausal Woman with Inflammatory Bowel Disease

08/07/2025

CONCLUSION: As the population of women with IBD age, individualized care for this population is increasingly important. This review highlights key health maintenance needs and provides a practical overview to care for this commonly overlooked patient population.

Assessing the Reliability of Combined Scales for Spirituality Perception and Web Course Learning Adaptation among Chinese Undergraduate Nursing Students

08/07/2025

Spiritual care aims to address the requirements of the human spirit in times of trauma, disease, or grief. The purpose of this study is to examine the internal consistency and construct validity of the Spiritual Cognition Scale for Chinese context when applied with the Online Course Learning Adaptation Scale among the nursing undergraduates. A total of 228 research samples were included in this quantitative, cross-sectional study, which utilized a 1:5 standard and accounted for a 20% loss. The...

Increasing age at diagnosis raises malignancy risk and aminosalicylate intolerance influences therapeutic strategies in ulcerative colitis: a multicenter I‑BRITE cohort study

08/07/2025

CONCLUSIONS: In the recent diagnostic era, the increase in elderly onset UC has been accompanied by a higher malignancy risk, favoring vedolizumab as first-line ADT, especially in elderly patients. Increased aminosalicylate intolerance has led to earlier initiation of systemic steroids and ADTs, which may contribute to improved outcomes.

Safety of early oral refeeding in patients with chronic pancreatitis after extracorporeal shock wave lithotripsy of pancreatic stone (SHEEL): A multicenter randomized controlled trial

08/07/2025

BACKGROUND: Fasting after extracorporeal shock wave lithotripsy (ESWL) is often used to avoid pancreas injury and reduce risk of pancreatitis. However, the optimal timing of oral refeeding after ESWL remains unclear. This study evaluates the impact of early oral refeeding on post-ESWL pancreatitis.

Construct Validity of the Toronto IBD Global Endoscopic Reporting Score Compared to Inflammatory Biomarkers After 12-Month Follow-Up

08/07/2025

CONCLUSIONS: The TIGER score is a simple endoscopic score that can be used for both CD and UC that has been shown to have both construct validity with inflammatory marker and noninferiority to the current best-referenced endoscopic scores over a 12-month follow-up period. Future studies should begin incorporating TIGER as a measure of clinical response to interventions and therapeutics.

Investigating Airway Symptoms in Eosinophilic Esophagitis (EoE)

08/07/2025

CONCLUSION: Airway symptoms in pediatric EoE can overlap with other conditions, complicating diagnosis. Key features such as adaptive eating behavior and food allergies should raise suspicion for EoE.

Mebendazole as an Adjunct Therapy with Mesalamine to Increase Efficacy and Maintenance Therapy for Ulcerative Colitis Patients: A Pilot Study

08/07/2025

CONCLUSION: The addition of mebendazole to mesalamine for UC treatment appears to be a safe and potentially beneficial approach to enhance mesalamine's efficacy and reduce clinical symptoms. However, given the small sample size and the short study duration, further large-scale, long-term trials are necessary to validate these preliminary findings.

The potential utility of CHATGPT4.0 as an AI assistant in the education and management of patients with Barrett's esophagus

07/07/2025

Chat Generative Pre-trained Transformer (ChatGPT) has emerged as a new technology for physicians and patients to obtain medical information. Our aim was to assess the ability of ChatGPT 4.0 to deliver high-quality information in response to commonly asked questions and management recommendations for Barrett's esophagus (BE). Twenty-nine questions (14 clinical vignettes and 15 frequently asked questions (FAQ)) on BE were entered into ChatGPT 4.0. Using a 5-point Likert scale, three...

Recombinant Herpes Zoster Vaccine Lowers Shingles Complication Risk in Patients with Inflammatory Bowel Disease

07/07/2025

CONCLUSIONS: RZV substantially lowers the risk of HZ complications in patients with IBD, offering significant clinical benefits to those at high risk due to immunosuppression. These findings underscore the importance of RZV as part of preventive care strategies in patients with IBD.

<em>Ketone metabolites in metabolic dysfunction-associated steatotic liver disease progression: optimizing keto-therapeutic strategies</em>

07/07/2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from simple steatosis to hepatocellular injury, inflammation, and fibrosis, ultimately leading to end-stage liver disease. Despite its rising prevalence, treatment options remain limited, highlighting the need for novel therapeutic strategies. In recent years ketone metabolism has emerged as a key modulator of hepatic metabolic health. Hepatic ketogenesis provides a mechanism for fatty acid mobilization. Endogenously...

Non-invasive colorectal cancer screening: simple may be optimal

07/07/2025

No abstract

Reply: Clarifying the impact of response criteria and locoregional therapy on complete response outcomes in patients with hepatocellular carcinoma following immunotherapy

07/07/2025

No abstract
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