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PublicationsPublications

Objectively Measured Smartphone Use and Nonsuicidal Self-Injury Among College Students: Cross-Sectional Study

30/07/2025

CONCLUSIONS: These findings emphasize that ≥63 hours per week of smartphone screen time and ≥400 times per week of smartphone unlocks are risk factors for NSSI among college students, and interventions targeting NSSI should consider the apparent association with smartphone use.

Alcohol-associated liver disease is associated with less adverse outcomes compared to nonalcohol-associated liver disease in patients with COVID-19

30/07/2025

CONCLUSIONS: In this large cohort of hospitalized COVID-19 patients, the presence of liver disease increased the odds of all tested adverse outcomes with a mortality gradient that correlated with the severity of liver disease. When compared to liver disease not related to alcohol, ALD was associated with reduced odds of mortality, assisted ventilation, and ICU admission.

An unusual etiology of diarrhea: primary intestinal lymphangiectasia

30/07/2025

Primary intestinal lymphangiectasia (PIL) is a rare disorder characterized by malformed and dilated intestinal lymphatic vessels, resulting in impaired drainage and leakage of lymph fluid into the gastrointestinal lumen. This leads to protein-losing enteropathy, causing chronic diarrhea, peripheral edema, weight loss, and hypoalbuminemia due to loss of proteins, lymphocytes, and lipids. Diagnosis relies on endoscopic visualization of pathognomonic white mucosal plaques (representing dilated...

The invisible burden - The challenge of untreated hepatocellular carcinoma

30/07/2025

This editorial explores the situation of patients with hepatocellular carcinoma (HCC) who, due to advanced frailty, multiple health conditions, personal choice, or terminal disease stage, are not candidates for active cancer treatment. Despite progress in early diagnosis, a notable percentage of these individuals receive only comfort-oriented care. The article reviews how their prognosis is largely determined by the severity of liver failure and overall health status, while tumor features such...

Cystic pancreatic lesions: when to watch and when to act?

30/07/2025

Cystic pancreatic lesions (CPL) represent a growing challenge in gastroenterology, as their detection becomes more prevalent, and their management is increasingly complex. While many CPLs are benign and require only observation, others carry a significant risk of malignant transformation. The key to effective management relies in an accurate risk stratification, which can guide decisions regarding surveillance and treatment. As we move towards more personalized, patient-centered approaches, it...

Temporal characterization of the gut microbiome and metabolome in preterm infants

30/07/2025

Preterm infants experience abnormal microbial colonization, which coupled with their vulnerable physiology can increase the risk of disease. Understanding the factors influencing the complex relationship between the temporal development of the gut microbiome and functional metabolites derived from microbe-microbe and microbe-host interaction is therefore critical. In this study, 266 longitudinal stool samples from 66 very preterm infants underwent 16S rRNA gene sequencing to analyse gut...

Actual and perceived risk of colorectal neoplasia in first-degree relatives of colorectal cancer patients

30/07/2025

CONCLUSION: Within a cohort of individuals aged 40-54 years with a FH of CRC, obesity, smoking and lack of physical activity represented the most prominent modifiable risk factors for the development of advanced colorectal neoplasia but did not significantly impact risk perception in these high-risk participants.

Marked pancreatic atrophy and calcification after immune checkpoint inhibitor-related pancreatic injury

30/07/2025

No abstract

Unprecedented Duodenal Erosion of a Transjugular Intrahepatic Portosystemic Shunt Stent: A Rare Trigger for Recurrent Polymicrobial Sepsis

30/07/2025

No abstract

Severe Complications of a Massively Enlarged IPMN

30/07/2025

No abstract

Epidemiologic Trends in Acute, Chronic, and Pregnancy-Specific Liver Diseases in Pregnancy

30/07/2025

CONCLUSION: In this large epidemiologic study, we observed a 2.5-fold rise in CLD in pregnancy over the past 10 years, largely driven by the rising prevalence of MASLD, and declining prevalence of chronic viral hepatitis. Pregnancy-specific liver conditions were also significantly more common in those with CLD. Findings underscore the relevance of pre-conception counseling by hepatology providers and the importance of early obstetric collaboration to optimize outcomes for the growing number of...

Intraductal Papillary Mucinous Neoplasm and Pancreatic Cancer: Opportunity Knocks Twice

30/07/2025

Pancreatic cystic lesions are widely recognized as harbingers of pancreatic cancer. Intraductal papillary mucinous neoplasm (IPMN) is the most common type of cystic lesion, offering promising avenues for early diagnosis of pancreatic cancer. Although IPMN has a well-established malignant potential, the wide variation in cancer risk necessitates prolonged surveillance for most patients. There is an unmet need to optimize surveillance strategies for patients with IPMNs to address the rising global...

Inflammatory bowel disease and risk of more than 1500 comorbidities: A disease-wide pre- and post-diagnostic phenomic association study

30/07/2025

CONCLUSION: Findings demonstrate that IBD is a multisystemic disease, particularly manifesting with metabolic, immune, and neuropsychological disorders, up-to 10 years prior to diagnosis. We find evidence for the generality of these findings with an international comparison. Diseases of etiological interest warrant further investigation.

Dysregulation of hepatic deiodinase type I in metabolically associated steatotic liver disease

30/07/2025

Hepatic thyroid hormone action plays an important role in preventing the development and progression of metabolic liver diseases, as evidenced by the recent success of the receptor-specific agonist resmetirom. The liver enzyme deiodinase type I (DIO1) is important for controlling the local availability of thyroid hormone, and gets upregulated in metabolically associated steatotic liver disease (MASLD), which is thought to be a compensatory mechanism to enhance local hormone action. However, it...

Pressure Tactic: Pancreato-Biliary Maljunction-Newer Insights into Pathophysiology and Management

30/07/2025

No abstract

Incidence and risk factors for skin cancer in liver transplant recipients: A systematic review

29/07/2025

Skin cancer is a frequent complication of liver transplantation; however, contemporary incidence rates and associated risk factors remain poorly defined. We conducted a systematic review to summarize the literature on the incidence and risk factors of skin cancer after liver transplant. In July 2024, we searched MEDLINE, CINAHL, EMBASE, ClinicalTrials.gov, ProQuest Dissertations and Theses, and conference proceedings for studies on skin cancer following adult liver transplantations. Primary...

Editorial overview

29/07/2025

No abstract

The Brescia International Multidisciplinary Consensus Guidelines on the Optimal Pathology Assessment and Multidisciplinary Pathways of Non-Pancreatic Neoplasms in and Around the Ampulla of Vater (PERIPAN)

29/07/2025

CONCLUSIONS AND RELEVANCE: Recognition of the Brescia PERIPAN guidelines will allow a more accurate classification of true ampullary cancers and their differentiation from other "periampullary" tumors. This will have significant implications for endoscopic interpretation and management, staging, pathologic diagnosis and therapeutic evaluation as well as oncologic treatment of various anatomic and histologic subsets of ampullary tumors. This will enhance the quality of both clinical care and...

Knockdown of Salusin-β Downregulates FTO to Inhibit Lipid Synthesis and Promote Lipolysis to Attenuate NAFLD

29/07/2025

CONCLUSIONS: In conclusion, knockdown of Salusin-β reduced FTO production, thereby alleviating lipid metabolism disorders. This provides a potential mechanism for elucidating the reduction of lipid metabolism by knockdown of Salusin-β and a potential target for the treatment of NAFLD.

The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm

29/07/2025

CONCLUSIONS: The current clinical landscape of chronic HDV infections in Italy is heterogeneous, changing the perspective of CHD as uniformly severe; although cirrhosis remains common, a substantial proportion of both native Italians and migrants present with milder forms of disease.
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