GHAPPcast: Mental Health Issues and Symptoms Related to IBS-C

July 2025

In this insightful episode, GI nurse practitioners Mary Clarke, Kristina Skarbinski, and Monica Nandwani explore the powerful connection between mental health and irritable bowel syndrome (IBS)—with a focus on IBS-C. The discussion highlights how stress, poor sleep, and emotional health can significantly impact gut function and symptom severity. Drawing on the updated 2024 Real-World IBS Survey, the team shares data showing how IBS affects quality of life, from daily discomfort to dietary restrictions and social withdrawal. Mary reviews how stress alters gut motility and gut-brain signaling, while Christina outlines pharmacologic strategies like neuromodulators (e.g., TCAs, SNRIs, SSRIs) and behavioral therapies including CBT and gut-directed hypnotherapy. The conversation also dives into dietary considerations, such as the low FODMAP diet, food reintroduction strategies, and identifying common symptom-triggering foods. Monica emphasizes the importance of collaborative care involving dietitians, psychologists, and telehealth resources to create a personalized treatment plan. This episode offers a practical, compassionate, and multidisciplinary approach to managing IBS-C through both medical and lifestyle interventions. Learn more at GHAPP.org or by downloading the GHAPP ACE App for on-the-go access to IBS education and resources.