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PublicationsPublications

Decoding liver risk: A deep dive into the Baveno VII "Rule-of-Five" criteria

18/07/2025

No abstract

Better late than resectable: Combination therapy finds its moment

18/07/2025

No abstract

Deep learning's crystal ball: Predicting HCC surgery success with multimodal imaging

18/07/2025

No abstract

Contingency management and the expanding role of hepatology in alcohol use disorder

18/07/2025

No abstract

Spatiotemporal analysis of Crohn's disease reveals PECAM2 signaling at the basis of inflammation-to-fibrosis transition

18/07/2025

CONCLUSIONS: Our results provide insights into CD38-driven fibrosis and indicate that PECAM2 signaling blockade could reduce the development of strictures in patients with Crohn's disease, potentially offering a new treatment target.

Day 3 Oxford Criteria Predict Steroid non-response for Acute Severe Ulcerative Colitis in the Post Biologic Era

18/07/2025

CONCLUSIONS: Day-3 Oxford criteria was an independent predictor of steroid non-response. The risk of colectomy remains substantial after discharge despite low in-hospital colectomy rate following an episode of ASUC. Initial steroid response did not affect long-term colectomy rate at 12 months.

OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation

18/07/2025

Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on the pathophysiology of intestinal fibroblasts remains poorly understood. Here, we demonstrate that OTU deubiquitinase 3 (OTUD3) suppresses pathologic activation of fibroblasts exposed to microbial cyclic GMP-AMP (3'3'-cGAMP) in the colon by deubiquitinating...

Liver cirrhosis in 2021: Global Burden of Disease study

18/07/2025

CONCLUSIONS: The growth of NAFLD and alcohol-related cirrhosis undermines progress in controlling HBV and HCV. Targeted prevention and management strategies are needed, especially in regions with low and middle SDI, which show higher cirrhosis mortality. For China, early intervention for NAFLD and continued control of HBV and HCV are critical to reduce the cirrhosis burden.

Volumetric Changes in Perianal Fistulizing Crohn's Disease Measured by Magnetic Resonance Is Feasible and Could Be a Potential Biomarker to Predict Clinical Outcomes

18/07/2025

CONCLUSION: Changes in the 3D MRI volumetry of perianal fistulas might have value in predicting clinical remission. Specifically, the reduction in the volumetry of the active component emerges as a promising biomarker for assessing therapeutic response.

Acute peritoneal propagation of alveolar echinococcosis in a 12-year-old child

18/07/2025

Herein we present a case of a 12-year-old child with acute symptoms (abdominal pain, fever). Preliminary imaging suggested pyogenic liver abscess. Despite the broad-spectrum antibiotic therapy, which was started after hospital admission, no improvement was perceived. Rising eosinophilia and multiplex focal lesions detected by ultrasound and MRI forced serological investigation by which Echinococcus granulosus s.l. seropositivity was detected. Antihelminthic therapy was initiated and upon...

circRNA_Atp8a1 Promotes Glycolytic Reprogramming in Damage of Intestinal Mucosal Barrier by Upregulating IGF2 through miR-200b-3p

18/07/2025

CONCLUSION: Circ_Atp8a1 plays a key regulatory role in the process of intestinal mucosal damage and affects the process of glycolysis through adsorption of miR-200b-3p to regulate IGF2. It is expected to be a new target for the treatment of intestinal mucosal damage.

Deep learning-based automatic detection of pancreatic ductal adenocarcinoma ≤ 2 cm with high-resolution computed tomography: impact of the combination of tumor mass detection and indirect indicator evaluation

18/07/2025

CONCLUSIONS: Combining indirect indicator evaluation with tumor mass detection may improve small PDAC detection accuracy.

Primary non-hepatoblastoma liver tumors in children-Defining the profile of a very rare subset of childhood tumors

18/07/2025

CONCLUSIONS: There was a high proportion of malignant rhabdoid tumors and higher serum AFP levels in HCC in our cohort. The overall outcomes of treated malignant tumors were relatively favorable, though limited by the sample size in this rare cohort.

Acute pancreatitis: Translating early mechanisms to bedside management

18/07/2025

Acute pancreatitis (AP) is a burgeoning challenge. The first week of the disease is generally considered early AP. Events that occur during this phase can determine the magnitude of subsequent events. Even after decades of research, there is still no curative therapy for early AP. One of the earliest events of clinical AP is the co-localization of zymogen and trypsinogen within autophagolysosome which is followed by trypsin activation. The resulting acinar injury releases damaged-associated...

Hepatic focal nodular hyperplasia after liver transplantation: case report and review of literature

18/07/2025

Patients with decompensated cirrhosis complicated by hepatocellular carcinoma (HCC) or those who have undergone liver transplantation following liver failure after HCC treatment should continue to receive post-transplant surveillance. Any new liver tumor must be carefully evaluated to determine whether it is a recurrence of HCC. Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor, is believed to result from the hyperplastic response of hepatocytes to pre-existing...

Liver Dysfunction and Liver Histopathology in Alanyl-tRNA Synthetase 1 (<em>AARS1</em>) Deficiency with a Novel Mutation: A Case Report

17/07/2025

Alanyl-tRNA synthetase 1 (AARS1) is a cytosolic enzyme belonging to the Aminoacyl transfer RNA synthetases group that plays a key role in protein translation. Bi-allelic AARS1 mutations presenting as liver dysfunction are rare. A 10-month-old baby girl presented with upper gastrointestinal bleeding and abdominal distension after a short history of febrile illness. There was hepatosplenomegaly with poor growth, microcephaly and delayed developmental milestones on examination. Laboratory...

Contrast-Enhanced Ultrasound in the diagnosis of Pseudomyxoma peritonei; a case report

17/07/2025

Pseudomyxoma peritonei (PMP) is a rare malignancy marked by mucinous ascites from neoplastic cell dissemination. We report a 50-year-old male with abdominal pain, weight loss, and ascites, initially suspected as hepatic metastases. Imaging revealed peritoneal implants and characteristic liver scalloping, but the percutaneous biopsy was inconclusive. Notably, contrast-enhanced ultrasound (CEUS) reproduced the hepatic scalloping typically seen on CT, helping distinguish mucinous peritoneal...

Characteristics of Clinical Studies on Gastroparesis Registered in ClinicalTrials.gov-A Cross-Sectional Analysis

17/07/2025

CONCLUSION: Despite increasing overall research activity on CTG, clinical trials in GP have remained relatively stagnant, with fewer interventional and early-phase trials in recent years. The high discontinuation and low completion rates, along with limited industry sponsorship, highlight significant barriers to advancing GP therapeutics. Attention is needed from the industry and policymakers to bring focus on the development of therapeutic solutions for improved clinical outcomes.

Accelerometer-measured circadian alignment predicts all-cause and cardiovascular mortality in middle-aged and older adults

17/07/2025

CONCLUSIONS: A lower phasor magnitude and both advanced and delayed phasor angles were associated with higher all-cause and CVD-specific mortality. Circadian metrics may serve as biomarkers to inform wearable-based monitoring and behavioral interventions.

Recent evolution of the developing human intestine affects metabolic and barrier functions

17/07/2025

Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human environment. Here, we interrogate the evolution of cell types in the developing human intestine by comparing tissue and organoids from humans, chimpanzees, and mice. We find that recent changes in primates are associated with immune barrier function and lipid/xenobiotic metabolism, and that...
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