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PublicationsPublications

Development of a targeted oral pharmacologic duodenal exclusion therapy for the treatment of metabolic diseases

30/05/2025

Type 2 diabetes (T2D) and obesity are chronic metabolic diseases with global morbidity and mortality. Decades of evidence from surgical and endoscopic procedures bypassing the duodenum underscore the duodenum's critical role in regulating glycemia and body weight. Although metabolic surgeries and endoscopic procedures are effective, their invasiveness, cost, and scalability limit patient access. We developed an orally administered mucin complexing polymeric (MCP) drug, designed to replicate...

A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression

30/05/2025

Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal process that afflicts approximately 10% of preterm infants born in the United States each year, with a mortality rate of 30%. NEC severity is graded using Bell's classification system, from stage I mild NEC to stage III severe NEC. Over half of NEC survivors present with neurodevelopmental impairment during adolescence, a long-term complication that is poorly understood. Although multiple animal models exist, none prospectively...

Bariatric surgery for metabolic dysfunction-associated steatotic liver disease (MASLD): Current knowledge of mechanisms

30/05/2025

Metabolic dysfunction-associated steatotic liver diseases (MASLD) encompass a spectrum of liver disorders primarily defined by hepatic steatosis and cardiometabolic risk factors. MASLD affects over 30% of the global adult population, representing a substantial risk for public health. MASLD can progress from simple steatosis to steatohepatitis (termed MASH) marked by inflammation and fibrosis, potentially leading to cirrhosis and liver cancer. Obesity has been identified as one of the leading...

Efficacy of Endoscopic Sutured Gastroplasty on Diabetes Mellitus Type 2-A Systematic Review

30/05/2025

CONCLUSION: This systematic review on the efficacy of ESG on T2DM suggests that ESG is able to improve diabetes-related outcomes in approximately half of treated patients, with T2DM remission rates in more than half of them.

Fully Closed-Loop Improves Glycemic Control Compared with Pump with CGM in Adolescents with Type 1 Diabetes and HbA1c Above Target: A Two-Center, Randomized Crossover Study

30/05/2025

Introduction: Adolescents with type 1 diabetes (T1D) can struggle to reach recommended HbA1c targets more than other age groups. The safety and efficacy of fully closed-loop (FCL) insulin delivery, which does not require mealtime bolusing, have not been assessed in this cohort. We evaluated the use of FCL with faster insulin aspart (Fiasp) in adolescents with T1D whose HbA1c was above recommended targets. Materials and Methods: This two-center, randomized, crossover study included 24 adolescents...

Hybrid Closed-Loop Therapy in Adults with Type 1 Diabetes in England: Long-Term Outcomes from a Real-World Observational Study

30/05/2025

Objective: To evaluate longitudinal real-world outcomes in adults with type 1 diabetes initiating hybrid closed loop (HCL). Methods: Adults with type 1 diabetes, managed with an insulin pump and intermittently scanned continuous glucose monitoring with hemoglobin A1c (HbA1c) ≥8.5% (69 mmol/mol), were started on HCL between August and December 2021 as part of the National Health Service England HCL pilot. We collected outcomes, including change in HbA1c, sensor glucometrics, Gold score...

Diverse Roles and Characteristics of Academic Research Organizations in Japan: Results of A Questionnaire-Based Study

30/05/2025

CONCLUSION: The roles and ultimate goals of AROs vary across institutions, highlighting the need for alignment with each institution's clinical research priorities and principles.

Identification of a migracytosis and angiogenesis-associated lncRNAs signature in immunotherapy in breast cancer

30/05/2025

Migracytosis and angiogenesis were crucial in breast cancer (BRCA) progression. This study aimed to develop a prognostic signature based on migracytosis- and angiogenesis-related lncRNAs. All genetic and clinical data of BRCA were acquired from The Cancer Genome Atlas (TCGA) database. A prognostic signature consisting of six lncRNAs (YTHDF3-AS1, AC018445.5, AP005131.1, AC010531.3, MIR200CHG, and AC000067.1) was established through correlation and Cox regression analysis, as well as the least...

Retrieval Basket Impaction During Pancreatoscopy-Guided Stone Removal

30/05/2025

No abstract

Advantages of deep learning reconstruction algorithm in ultra-high-resolution CT for the diagnosis of pancreatic cystic neoplasm

30/05/2025

CONCLUSION: DLR improved image quality and diagnostic performance by effectively reducing image noise and improving lesion conspicuity in the diagnosis of PCNs on UHR-CT. The DLR demonstrated greater diagnostic confidence for the assessment of imaging findings associated with PCNs.

Carbon footprint of common procedures in inflammatory bowel disease

30/05/2025

CONCLUSIONS: The carbon footprint of three commonly performed IBD surgeries is mainly determined by transportation of patients/healthcare personnel, followed by electricity and material use. The latter two vary with the complexity of the surgeries. IBD surgeons should focus on minimizing energy resources and using standard surgical materials. Also, employees should be encouraged to travel by foot/bicycle/public transport/carpooling/electric car.

Risk of atherosclerotic cardiovascular disease after cancer diagnosis: findings from three prospective cohort studies

30/05/2025

CONCLUSIONS: Cervical cancer or Hodgkin lymphoma was associated with an increased risk of new-onset ASCVD, independent of shared risk factors, while no increased risk was found with other cancers. ASCVD risk trajectories varied over time after diagnosis according to cancer types.

The Effects of a Virtual Rainforest and Portable Water Wall Application on Patient Satisfaction, Comfort, Anxiety, and Vital Signs Before Colonoscopy: A Randomized Clinical Trial

30/05/2025

CONCLUSIONS: According to the study results, precolonoscopy PW and VRF reduced anxiety, increased satisfaction and comfort, and had a positive effect on vital signs. The results of this study will contribute to evidence-based nursing practices for disturbances associated with colonoscopy. PWs' sound and visual elements can have a calming and relaxing effect, and VR is a simple, affordable technology that can be used to provide patients better care.

Beyond the Black Box: Explainable AI Transforms Hepatocellular Carcinoma Diagnosis at MRI

30/05/2025

No abstract

Interactive Explainable Deep Learning Model for Hepatocellular Carcinoma Diagnosis at Gadoxetic Acid-enhanced MRI: A Retrospective, Multicenter, Diagnostic Study

30/05/2025

Purpose To develop an artificial intelligence (AI) model based on gadoxetic acid-enhanced MRI to assist radiologists in hepatocellular carcinoma (HCC) diagnosis. Materials and Methods This retrospective study included patients with focal liver lesions (FLLs) who underwent gadoxetic acid-enhanced MRI between January 2015 and December 2021. All hepatic malignancies were diagnosed pathologically, whereas benign lesions were confirmed with pathologic findings or imaging follow-up. Five manually...

Dietary Intake of Major Minerals and Trace Elements in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Implications for Dietary Intervention

29/05/2025

CONCLUSION: Patients with MASLD consumed greater amounts of most minerals than did the control group due to overeating. When diet modification for patients with MASLD is planned, the intake of calcium, zinc, and boron needs to be controlled, and the diet may be modified with food supplements or specific foods rich in these minerals.

Oral Peptide Therapeutics as an Emerging Treatment Modality in Immune-Mediated Inflammatory Diseases: A Narrative Review

29/05/2025

Immune-mediated inflammatory diseases (IMIDs), such as psoriasis, psoriatic arthritis, and inflammatory bowel disease, encompass a heterogenous group of conditions associated with chronic inflammation. Systemic treatments for patients with IMIDs include parenterally delivered monoclonal antibodies (mAbs) that disrupt specific cytokine and cytokine receptor binding interactions, and orally delivered small molecules that inhibit certain enzymes involved in the regulation of inflammatory signaling....

Opium addiction is associated with increased risk of ERCP-related complications: A matched case-control study

29/05/2025

CONCLUSION: ERCP could be associated with higher rate of complications in opium-addict patients. Accurate procedural techniques and appropriate prophylaxis should be considered to reduce the risk of complications.

Opioid addiction: A new risk factor for adverse events after endoscopic retrograde cholangiopancreatography?

29/05/2025

No abstract

Efficacy and safety of immediate vs. delayed endoscopic retrieval of large or multiple common bile duct stones in high-risk elderly patients: a prospective, randomized comparative study

29/05/2025

CONCLUSION: In high-risk elderly patients with large or multiple CBD stones, temporary placement of biliary plastic stents followed by elective endoscopic stone removal effectively reduces stone size, simplifies the removal process, enhances stone clearance rates, and decreases ERCP-related complications.
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