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PublicationsPublications

Exploring <em>APC</em> Mosaicism in Upper Intestinal Tract Adenomas

16/09/2025

No abstract

Vaccination among splenectomy patients: can unavailability or ignorance justify failure in administration?

16/09/2025

Splenectomy (elective or emergency) increases susceptibility to life-threatening infections, particularly overwhelming post-splenectomy infection (OPSI) from encapsulated organisms. Despite clear guidelines recommending pneumococcal, meningococcal, haemophylus, and influenza vaccinations, coverage remains suboptimal, especially in low-resource settings such as India. Poor vaccine uptake is driven by a lack of awareness among patients and providers, financial constraints, limited availability,...

Kidney Tubule Secretion Can Discriminate the Cause of Acute Kidney Injury in Cirrhosis

16/09/2025

CONCLUSIONS: In patients with cirrhosis and AKI, substantially lower tubular secretion was observed among inpatients with ATN relative to those with PRA and HRS. These results support the use of tubular secretion for the differential diagnosis of AKI in cirrhosis and may have important therapeutic and prognostic implications.

Rapid cyclic stretching of cultured human visceral smooth muscle cells promotes a synthetic, proinflammatory phenotype

16/09/2025

Bowel smooth muscle experiences mechanical stress constantly during normal function, and pathologic mechanical stressors in disease states. We tested the hypothesis that pathologic mechanical stress could alter transcription to induce smooth muscle phenotypic class switching. To test this hypothesis, primary human intestinal smooth muscle cells (HISMCs), seeded on electrospun aligned poly-ε-caprolactone nano-fibrous scaffolds, were subjected to pathologic, high frequency (1 Hz) uniaxial 3%...

miR147 promotes mucosal integrity and healing in intestinal inflammation

16/09/2025

The intestinal mucosal epithelium forms a barrier between luminal contents and the body. microRNAs (miRNAs) regulate mucosal homeostasis by controlling inflammatory responses and structural integrity. Here, we discovered a protective role for miR147 in intestinal inflammation using a miR147tdTomato reporter mouse. miR147 was enriched in the intestines, with the highest expression in the colonic epithelial cells at the luminal surface, with prominent expression in differentiated enterocytes. Mice...

Is it simpler with single-port?. A comparative analysis of single-port robot-assisted simple and radical nephrectomy in a tertiary referral center

16/09/2025

CONCLUSIONS: SP-RASN is a feasible option for the management of benign renal conditions/diseases, offering a low postoperative complication rate and the possibility of SDD.

Safety and Efficacy of Ustekinumab and Vedolizumab Among Older Adults with Inflammatory Bowel Disease

16/09/2025

CONCLUSION: The use of UST and VDZ had similar efficacy and safety outcomes in older adults as compared to younger individuals with IBD. Decisions to utilize these biologics should be driven by overall disease burden and comorbidities, and not be deferred due to advanced chronological age alone.

Impact of malnutrition on liver and spleen stiffness in children evaluated by shear wave elastography

16/09/2025

CONCLUSION: Our findings indicate that malnutrition is associated with age- and severity-dependent alterations in liver and spleen stiffness. Liver stiffness was elevated only in children with severe malnutrition, whereas spleen stiffness was reduced in younger children but not in older ones. SWE may serve as a valuable non-invasive tool for assessing organ-level effects of malnutrition, and these results may guide future research on the reversibility and clinical significance of such changes.

Association of leptin levels and relative leptin deficiency with steatotic liver disease in the general population

16/09/2025

No abstract

Characterization of gastroesophageal reflux in patients during anesthesia induction: a high-resolution impedance manometry study

16/09/2025

CONCLUSION: Up to 42.9% of patients experienced reflux within 10 min of anesthesia induction, with the majority occurring within 5 min. The gastroesophageal reflux during anesthesia induction was related to TLESR, not to a decrease in gastroesophageal BrP.

Tiprelestat for treatment of hospitalized COVID-19: results of the double-blind randomized placebo-controlled COMCOVID trial

16/09/2025

CONCLUSION: Tiprelestat infused for 30 min twice daily in patients with moderate COVID-19 requiring hospitalization was well tolerated and appears to be safe. Beneficially, plasma trough levels of the drug over time were high and stable. The small sample size does not facilitate reliable statements about efficacy. Further studies are necessary including other inflammatory severe respiratory diseases.

Takayasu Arteritis with Fistulizing Crohn's Disease: A Rare Presentation

16/09/2025

Crohn's disease (CD) is a chronic, recurrent, transmural inflammatory disease with lesions anywhere in the gastrointestinal (GI) tract. Takayasu arteritis (TA) is an idiopathic, chronic, granulomatous inflammatory panarteritis that involves the aorta and its branches, known as "pulseless disease." Crohn's disease and TA are both associated, as both are granulomatous disorders, and multiple cases of simultaneous occurrence of both diseases have been reported. Here we are reporting a rare case of...

To Compare between CTP, MELD, MELD-Na, MELD + HDLc, RDW, and RDW to Platelet Ratio as a Predictor of Short-term Mortality in Cirrhosis of Liver

16/09/2025

CONCLUSION: MELD along with MELD-Na scores constitute reliable indicators of mortality over the short term in individuals with cirrhosis and should be preferred in practice for assessing the need for LT and other critical interventions. These findings underscore the importance of using evidence-based scoring systems to improve patient management and outcomes in liver cirrhosis, a condition with a high global mortality burden.

Incidence and Pattern of Transfusion Reactions and its Association with Blood and its Components in a Tertiary Care Hospital

16/09/2025

CONCLUSION: The overall incidence of TRs was 0.18%. The incidence of actual TRs remains underestimated due to lack of awareness regarding TRs among healthcare professionals.

Current Status and Future Perspectives of Molecular Residual Disease Testing in Genitourinary Cancers

16/09/2025

While the clinical outcome for patients with resectable solid tumors has improved in recent years, the risk of postoperative recurrence underscores the need for effective monitoring in cancer patients. Molecular residual disease (MRD) refers to the presence of microscopic cancer that remains undetectable on conventional imaging or pathology. Because of the rapid advancement in circulating tumor DNA (ctDNA) analysis using next-generation sequencing technology, MRD testing using ctDNA has...

Viral Load-Based Prediction of Hepatocellular Carcinoma Risk in Noncirrhotic Patients With Chronic Hepatitis B

15/09/2025

No abstract

Probiotic-Mediated Regulation of Arginine Metabolism to Improve Intestinal Barrier Function: A Metabolic Makeover for IBD?

15/09/2025

No abstract

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

15/09/2025

Cystic Fibrosis (CF) is an inherited condition that impacts multiple organ systems, one of which is the liver. The presentation and manifestation of liver disease in CF are varied, and there is ongoing research to better understand its etiology and clinical implications. Some studies have shown that liver disease in CF impacts 10% of people with CF (PwCF) by age 10 and 30% by age 30. Screening and monitoring for hepatic involvement in CF continue to evolve as new guidelines and therapies are...

Inaccuracy and Bias in Endoscopic Size Estimation of Large Colorectal Polyps; Insights From a Prospective Cohort of 1828 En-Bloc Resections

15/09/2025

CONCLUSIONS: Endoscopic size estimation of large colorectal lesions can be inaccurate and influenced by digit bias, underscoring the need for improved measurement techniques (UMIN000010136).

Association Between Liver Fibrosis and Cause-Specific Mortality in Japanese Patients With Biopsy-Confirmed Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Cohort Study / Liver Fibrosis and Mortality in Japanese MASLD

15/09/2025

CONCLUSION: HCC and extrahepatic malignancies were the leading causes of death in Japanese patients with MASLD. Liver fibrosis was a significant predictor of both all-cause and liver-related mortalities, but not nonliver-related mortality, highlighting its importance in follow-up strategies for MASLD. MASH may contribute to increased nonliver-related deaths. Further long-term studies are warranted.
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